Purified Anti-Human CD221 Antibody[1H7] (AN008870P)
![Purified Anti-Human CD221 Antibody[1H7] - 1](http://file.elabscience.com/assets/images/loading.png)
| Alternate Names | JTK, IGF1R, CD221, IGFIR, IGFR, JTK13, CD221 antigen, IGF-1R, IGF-I R, IGF-I receptor, IGF-IR, insulin-like growth factor 1 receptor |
| Clone | |
| Verified Samples | Verified Samples in FCM: MCF-7 |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Immunogen | Recombinant Human CD221 protein |
| Abbre | CD221 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications |
FCM
|
| Research Areas | Cancer;Metabolism;Developmental Biology;Neuroscience;Signal Transduction;Cardiovascular Biology;Insulin?Signaling Pathway;Intracellular Kinases;Receptor Tyrosine kinases;Pluripotency Maintenance and Differentiation;AMPK Signaling Pathway;Diabetes;CDs;Angiogenesis;Heart disease;Tumor Biomarkers |
| Cellular Localization |
Cell membrane
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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